The quality and long-term performance of ligand-binding assays (LBAs) depends on ensuring reagent consistency throughout the variable production process, storage and then use. LBAs are widely used in drug discovery to detect and measure a molecule’s binding to a target to understand how it performs.
However, the specificity, selectivity and sensitivity of LBAs depend on the reagents used. Such reagents are considered ‘critical’ if their variation can have a significant effect on the assay outcome. Critical reagents may include binding proteins, aptamers, antibodies or conjugated antibodies, positive and negative controls, or reference standards.
Mosaic is designed to accurately track all sample types through their lifetime, including recording sample events from creation to disposal, monitoring of stock levels, and tracking sample locations, movements, expiry dates – all backed by a full audit trail. These capabilities make it ideally suited to critical reagent management.
Our application note discusses the lifecycle management procedures needed to ensure consistency between original and new batches of critical reagents and how to implement them.