In order to achieve the ultimate goal of getting drugs to patients faster, pharmaceutical companies need to speed up the screening cycle hand-in-hand with improving data quality. This requires a step change in drug discovery research and development.
Four life science automation and software vendors – Labcyte (now part of Beckman Coulter Life Sciences), Brooks Life Sciences, Tecan and Titian Software – have been working with a major pharmaceutical company to drive the sample management innovations necessary to achieve this step change.
Acoustic technologies (based around the Brooks AcoustiX® tube) were chosen as the foundation to deliver these sample management workflows for three reasons:
To achieve this aim of miniaturised and fully acoustic sample management required a partnership to bring together best-in-class solutions and ideas. Labcyte/Beckman Coulter, Brooks, Tecan and Titian have all had to produce innovations to make these acoustic workflows a reality, and their solutions have been reached by a true partnership and willingness to work closely together.
This matches Titian’s ethos, says Toby Winchester, automation product manager at Titian: “Titian’s view is that we don’t just work with one store or liquid handling manufacturer, we work with several. Partnering with different vendors allows the scientist to choose the best fit for their work. We also feel that no single company can do everything. Our specialisms lie in different places and together we can meet the exacting needs of our customers.”
Titian’s Mosaic software provides the sample management LIMS for two key reasons to do with usability:
To meet the demands of a fully acoustic workflow, Titian has had to extend its existing vendor integrations in order to simplify ordering and control throughout. Clever management of automation is needed to achieve the greater workflow efficiencies required of the system.
In effect, the Mosaic software has become the glue that fuses inputs from four companies into one smooth functioning system. For example:
However, the major development has been making the Labcyte/Beckman Coulter system easier to run for the operators. It only takes 5 clicks from opening the application to having the Access liquid handler start – it’s that simple. It has really streamlined the process.
This is achieved through Mosaic’s Tempo Fulfilment Module (TFM) application – Tempo being the software that runs the Access – which allows easy set-up of runs. There is no manual file handling, no spreadsheets are needed to calculate dose responses – this is all done automatically in the app. Mosaic includes calculations for the best fit of the curve. As the sample workflow progresses, Mosaic sweeps back in all the log files from bulk fillers, different liquid handlers, and even updates source plate and tube inventory with live survey data.
Toby says “For example, if there’s been some evaporation because the plate has been left unsealed too long, this is updated as the process goes along. Mosaic also provides a comprehensive audit trail so, if anything goes wrong, you can find the cause. Perhaps it might be some crystallisation of your substances in one of the tubes which caused a problem.”
Why is this tighter integration and streamlined processing necessary?
The main reason is performance. “Batch runs allow one set of runs to be done on one Echo and another on a different one, so you are doubling the speed. It allows queuing of batches, so you can do runs overnight,” says Toby.
The performance aspect goes further:
Toby says “Mosaic even reacts to the survey volumes, so if there is an air bubble because you haven’t centrifuged for long enough, the data is not only transferred to the destination plate but, because of the audit trail, you can trace that back to the tube that may have an issue, allowing you to inspect it and find the cause. It helps you keep your compound collection as good as possible.”
For scientists, this tight integration of lab automation with Mosaic software produce a profoundly simple but very effective result: they no longer need to interact with many different robots in order to create the final compound plate.
By partnering together to enable a fully acoustic workflow, the innovations driven by Labcyte/Beckman Coulter, Brooks, Tecan and Titian together have achieved:
We look forward to seeing further results as this innovative acoustic workflow drives a new era in drug discovery.
Learn more about how Mosaic’s TFM application is used to directly integrate Beckman Coulter’s Access workstation by in our app note: Easy Acoustic Automation Integration: Using Mosaic’s TFM Application with Beckman Coulter’s Acoustic Platforms. Click here to download the app note.
Download Titian's free white paper: The Essential Guide to Managing Laboratory Samples
Watch a video showing how easy it is to incorporate managing your liquid handlers into your LIMS tracking system.
In any case, consider talking to one of our Titian experts – there is a better way to manage your data flow!